METABOLIC FLUX ANALYSIS SERVICE
METABOLIC FLUX ANALYSIS SERVICE
01 Whole body amino acid flux
INTRODUCTION
Amino acids/protein metabolism is involved in supporting numerous biological reactions
in the body, particularly in muscle or heart.
Whole body amino acid flux can reflect net balance between disappearance of amino acids into tissues (protein synthesis) and appearance of amino acids released from tissues (protein breakdown).
Using labeled amino acids (D5-phenylalanine, D2- thyrosine or U-13C-leucine),
we can measure net balance, protein synthesis, and protein breakdown.
02 Amino acid oxidation
INTRODUCTION
Amino acids are metabolized in oxidative phosphorylation process, leading to production
of ATP and CO2.
Thus, oxidation of amino acids can reflect the capacity of protein utilization
as an energy source. Using carbon-labeled leucine (13C), we can determine in vivo protein oxidation.
03 Muscle, heart, other organ protein synthetic rate
INTRODUCTION
Protein turnover can replace older non-functional proteins to new functional proteins.
Changes in muscle mass are based on the net balance between protein synthesis and breakdown.
Using D5-phenylalanine or D2O, we can measure protein synthesis and breakdown in response to acute stimulations such as diet intake or exercise and long-term treatment such as exercise training, supplementation or drug.
04 Anaplerosis flux
05 Cataplerosis flux
INTRODUCTION
Amino acids/protein metabolism is involved in supporting numerous biological reactions
in the body, particularly in muscle or heart.
Whole body amino acid flux can reflect net balance between disappearance of amino acids into tissues (protein synthesis) and appearance of amino acids released from tissues (protein breakdown). Using labeled amino acids (D5-phenylalanine, D2- thyrosine or U-13C-leucine),
we can measure net balance, protein synthesis, and protein breakdown.
INTRODUCTION
Amino acids are metabolized in oxidative phosphorylation process, leading to production
of ATP and CO2.
Thus, oxidation of amino acids can reflect the capacity of protein utilization
as an energy source. Using carbon-labeled leucine (13C), we can determine in vivo protein oxidation.
INTRODUCTION
Protein turnover can replace older non-functional proteins to new functional proteins.
Changes in muscle mass are based on the net balance between protein synthesis and breakdown.
Using D5-phenylalanine or D2O, we can measure protein synthesis and breakdown in response to acute stimulations such as diet intake or exercise and long-term treatment such as exercise training, supplementation or drug.
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호스팅제공자: (주)아임웹
사업자등록번호: 597-86-02452
통신판매업신고: 2022-서울강남-04066호
소비자 상담: 070-4699-6564
© Myocare, Inc. All rights reserved.
주식회사 마이오케어ㅣ대표: 김일영ㅣ연락처: 070-4699-6564ㅣ 이메일: info@myocare.co.kr ㅣ 주소: 서울특별시 강남구 도산대로 145 인우빌딩 1204호
개인정보관리책임자: info@myocare.co.kr ㅣ 호스팅제공자: (주)아임웹
사업자등록번호: 597-86-02452 ㅣ 통신판매업신고: 2022-서울강남-04066호
소비자 상담: 070-4699-6564
© Myocare, Inc. All rights reserved.