METABOLIC FLUX ANALYSIS SERVICE
01 Whole body fatty acid flux flux/Lipolysis
INTRODUCTION
Lipid metabolism is involved in synthesis and breakdown (lipolysis) of fats for energy supply.
The synthesis is particularly processed in liver and the lipolysis occurs at adipose tissue.
Using D5-glycerol and D- or 13C-palmitate, we can determine whole body lipolysis and
fatty acid flux.
02 Fatty acid oxidation
INTRODUCTION
Fatty acid is metabolized in oxidative phosphorylation process, leading to production of ATP and CO2.
Thus, fatty acid oxidation can reflect the capacity of fatty acid utilization as an energy source.
Using U-13C palmitate, we can determine in vivo fatty acid oxidation.
03 De novo lipogenesis
INTRODUCTION
In the fed state, de novo lipogenesis (DNL) in liver is one of major sources to produce VLDL-TG.
DNL is derived from glucose, fructose and amino acids. Using D2O labeling, we can analyze
De novo lipogenesis and TG-turnover.
04 Triacylglycerol (TG) flux
05 TCA cycle flux
INTRODUCTION
Fatty acid is metabolized in oxidative phosphorylation process, leading to production of ATP.
Thus, fatty acid labeling in TCA cycle can reflect the capacity of fatty acid utilization as an
energy source.
Using U-13C plamitate, we can determine in vivo metabolites flux in TCA cycle.
INTRODUCTION
Lipid metabolism is involved in synthesis and breakdown (lipolysis) of fats for energy supply.
The synthesis is particularly processed in liver and the lipolysis occurs at adipose tissue.
Using D5-glycerol and D- or 13C-palmitate, we can determine whole body lipolysis and
fatty acid flux.
INTRODUCTION
Fatty acid is metabolized in oxidative phosphorylation process, leading to production of ATP and CO2.
Thus, fatty acid oxidation can reflect the capacity of fatty acid utilization as an energy source. Using U-13C palmitate, we can determine in vivo fatty acid oxidation.
INTRODUCTION
In the fed state, de novo lipogenesis (DNL) in liver is one of major sources to produce
VLDL-TG.
DNL is derived from glucose, fructose and amino acids. Using D2O labeling, we can analyze
De novo lipogenesis and TG-turnover.
INTRODUCTION
Fatty acid is metabolized in oxidative phosphorylation process, leading to production of ATP.
Thus, fatty acid labeling in TCA cycle can reflect the capacity of fatty acid utilization as an
energy source. Using U-13C plamitate, we can determine in vivo metabolites flux in TCA cycle.
주식회사 마이오케어 2023 MYOCARE INC.
주식회사 마이오케어ㅣ대표: 김일영ㅣ연락처: 070-4699-6564
이메일: myocare@myocare.co.kr
주소: 서울특별시 강남구 압구정로 8길 26, B1
개인정보관리책임자: myocare@myocare.co.kr
호스팅제공자: (주)아임웹
사업자등록번호: 597-86-02452
통신판매업신고: 2022-서울강남-04066호
소비자 상담: 070-4699-6564
© Myocare, Inc. All rights reserved.
주식회사 마이오케어ㅣ대표: 김일영ㅣ연락처: 070-4699-6564ㅣ 이메일: myocare@myocare.co.kr ㅣ 주소: 서울특별시 강남구 언주로 113길 7, 3층 330호
개인정보관리책임자: myocare@myocare.co.kr ㅣ 호스팅제공자: (주)아임웹
사업자등록번호: 597-86-02452 ㅣ 통신판매업신고: 2022-서울강남-04066호
소비자 상담: 070-4699-6564
© Myocare, Inc. All rights reserved.
